• Users Online: 1343
  • Home
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 1  |  Page : 89-91

Uric acid levels in patients on antituberculosis drugs in the southwest Region of Cameroon


1 Department of Medical Laboratory Science, Faculty of Health Sciences, University of Buea, Buea, Cameroon; Bacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana
2 Department of Medical Laboratory Science, Faculty of Health Sciences, University of Buea, Buea, ; Laboratory of Endocrinology and Radioelements (LERE), Medical Research Centre (CRM), Institute of Medical Research and Studies on Medicinal Plants (IMPM), Yaounde-, Cameroon
3 Department of Medical Laboratory Science, College of Medical Sciences, University of Calabar, Calabar, Nigeria
4 Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Ebonyi State University, Abakaliki, Nigeria
5 Department of Public Health and Hygiene, Faculty of Health Sciences, University of Buea, Buea, Cameroon

Correspondence Address:
Dr Benjamin David Thumamo Pokam
Department of Medical Laboratory Science, Faculty of Health Sciences, University of Buea, P. O. Box: 63, Buea

Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmy.ijmy_161_17

Rights and Permissions

Background: Antituberculosis drugs (ATDs) efficiently combat Mycobacterium tuberculosis either through direct molecular interactions or those of its metabolites. However, a variety of adverse effects have been reported, leading to frequent interruptions of treatment. To investigate the possible metabolic disturbances resulting from antituberculosis (TB) treatment, the uric acid (UA) level of patients on ATDs was measured in the southwest region of Cameroon. Methods: This hospital-based cross-sectional study involved 96 TB patients on ATDs and 32 controls who were neither on ATDs nor any other treatment that could increase UA levels. The hospital records of consenting participants were reviewed for medical history and questionnaires were issued. About 2 ml venous blood was collected and analyzed using spectrophotometers to determine UA levels. Results: Hyperuricemia was observed in 56/96 (58.3%) of the studied group as compared with 4/32 (12.5%) in the control group (P < 0.001). Our results indicated that treatment duration was significantly associated with hyperuricemia (P = 0.0016) while gender (P = 0.1275) was not. Conclusion: Hyperuricemia is associated with ATDs, with treatment duration being a significant factor. The disorder should be closely monitored, especially during the intensive phase of treatment.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed13031    
    Printed215    
    Emailed1    
    PDF Downloaded685    
    Comments [Add]    
    Cited by others 1    

Recommend this journal