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CASE REPORT
Year : 2022  |  Volume : 11  |  Issue : 1  |  Page : 120-122

Ethambutol-induced bullous skin lesions in mycobacterium kansasii lung infection


1 Department of Pulmonary and Critical Care; Salem VA Medical Center, Salem, VA; Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA
2 Department of Pulmonary and Critical Care; Salem VA Medical Center, Salem, VA, USA
3 Department of Infectious Disease, Salem VA Medical Center, Salem, VA, USA
4 Salem VA Medical Center, Salem, VA; Virginia Tech Carilion School of Medicine, Roanoke, Virginia; Department of Infectious Disease, Salem VA Medical Center, Salem, VA, USA

Correspondence Address:
Venkateswara K Kollipara
1970, Roanoke Blvd, Department of Pulmonary, Salem Veterans Affairs Medical Center, Salem, VA 24153
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmy.ijmy_204_21

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Mycobacterium kansasii is the second most common cause of nontuberculous mycobacterial (NTM) lung disease after Mycobacterium avium complex infection in the United States.[1] The first-line therapy for M. kansasii is a three-drug regimen including rifampin, isoniazid, and ethambutol. We present a case of a patient with pulmonary M. kansasii who developed bullous skin lesions while receiving this regimen and again after rechallenge with ethambutol. In patients with intolerance to one of the first-line antibiotics, a multidisciplinary team approach to starting second-line agents is needed. Ethambutol should be included in the differential diagnosis of drug-induced bullous skin lesions in treated patients with NTM, who develop new onset rash with blisters or ulceration.


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