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 Table of Contents  
LETTER TO EDITOR
Year : 2022  |  Volume : 11  |  Issue : 2  |  Page : 225

Genetic polymorphism of toll-like receptors in HIV-I infected patient and tuberculosis Co-Infection


1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India

Date of Submission18-Mar-2022
Date of Acceptance28-Mar-2022
Date of Web Publication14-Jun-2022
Date of Print Publicaton14-Jun-2022

Correspondence Address:
Rujittika Mungmunpuntipantip
Private Academic Consultant, 26 Bangkok 112 Bangkok 103300
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmy.ijmy_42_22

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How to cite this article:
Mungmunpuntipantip R, Wiwanitkit V. Genetic polymorphism of toll-like receptors in HIV-I infected patient and tuberculosis Co-Infection. Int J Mycobacteriol 2022;11:225

How to cite this URL:
Mungmunpuntipantip R, Wiwanitkit V. Genetic polymorphism of toll-like receptors in HIV-I infected patient and tuberculosis Co-Infection. Int J Mycobacteriol [serial online] 2022 [cited 2022 Jul 6];11:225. Available from: https://www.ijmyco.org/text.asp?2022/11/2/225/347515



Dear Editor,

We would like to share ideas on the publication “Genetic polymorphism of toll-like receptors in HIV-I infected patients with and without tuberculosis co-infection.[1]” According to Kaushik et al., the Asp299Gly polymorphism in the TLR4 gene is linked to higher susceptibility to active tuberculosis (TB) in HIV-positive patients.[1] Increased frequency of the “A” allele in the TLR9 gene was also discovered at the time of active TB development in ART-naive HIV+ patients who acquired active TB on follow-up, according to Kaushik et al.[1]

The Asp299Gly polymorphism in the TLR4 gene, we agree, could have clinical implications. On the other hand, various complicating variables should be considered. In addition to the Asp299Gly polymorphism in the TLR4 gene, there are other genetic variants that may be connected to TB co-infection in HIV. These polymorphisms include the rs12722 COL5A1 and rs3751143 P2X7 polymorphisms.[2],[3] More research is needed to establish if those variables have a confounding effect.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Kaushik G, Vashishtha R, Tripathi H, Yadav RN. Genetic polymorphism of toll-like receptors in HIV-I infected patients with and without tuberculosis co-infection. Int J Mycobacteriol 2022;11:95-102.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Keikha M, Karbalaei M. P2X7 polymorphism (rs3751143) and its reliability as a diagnostic biomarker for tuberculosis: A systematic review and meta-analysis. Indian J Tuberc 2022;69:85-9.  Back to cited text no. 2
    
3.
Zhetkenev S, Khassan A, Khamzina A, Issanov A, Crape B, Akilzhanova A, et al. Association of rs12722 COL5A1 with pulmonary tuberculosis: A preliminary case-control study in a Kazakhstani population. Mol Biol Rep 2021;48:691-9.  Back to cited text no. 3
    




 

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