Identification of Mycobacterium tuberculosis in pulmonary and extrapulmonary specimens of Iranian hospitalized patients during 2017–2021

Mohammadreza Salehi; Reza Shahsiah; Kiarash Mohammad Khorasani; Malihe Hasannezhad; Arian Rahimi; Bahare Yousefi; Amir Aliramezani

doi:10.4103/ijmy.ijmy_210_22

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ORIGINAL ARTICLE

Year : 2023 | Volume : 12 | Issue : 1 | Page : 23-27

Identification of Mycobacterium tuberculosis in pulmonary and extrapulmonary specimens of Iranian hospitalized patients during 2017–2021

Mohammadreza Salehi¹, Reza Shahsiah², Kiarash Mohammad Khorasani¹, Malihe Hasannezhad¹, Arian Rahimi³, Bahare Yousefi⁴, Amir Aliramezani⁵
¹ Department of Infectious Disease, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
² Department of Pathology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
³ Department of Biochemistry and Molecular Biology, School of Life Sciences, USTC, Hefei, China
⁴ Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
⁵ Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Kraków, Poland

Correspondence Address:
Amir Aliramezani
Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow 30-387
Poland

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/ijmy.ijmy_210_22

Background: Tuberculosis (TB) is one of the most serious public health problems worldwide which is a chronic infectious disease and is still one of the major challenges for developing countries. This study was undertaken to identify Mycobacterium TB (MTB) in clinical specimens in hospitalized patients. Methods: The study was carried out on specimens from pulmonary and extrapulmonary suspected TB patients that were admitted to one of the largest tertiary hospitals located in Tehran, Iran from 2017 to 2021. The GeneXpert MTB/rifampin (RIF) method was applied to detect MTB and RIF resistance. Characteristics of demography, clinical features, and lifestyle were obtained from medical case records registered in the hospital. Results: Of 957 specimens, 92 (9.61%) were found positive for TB by GeneXpert assay. Of positive samples, 72 (78.26%) were considered pulmonary TB, and 20 (21.73%) of them are associated with extrapulmonary involvement. Four (4.3%) positive TB cases were categorized as rifampicin-resistant. Conclusion: This study showed a relatively high incidence rate of TB in distinct types of specimens in Iranian hospitalized patients but a low level of RIF resistance.

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