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  Indian J Med Microbiol
 

Figure 6: (a) Trial sequential analysis of interferon-gamma +874T/A gene polymorphism in all the included studies. (b) trial sequential analysis of pulmonary tuberculosis cases in East Asian population. The required information size was calculated using two-sided α =0.05, β =0.20, relative risk reduction = 15% using the data of dominant model which was found to be 117,98 and 3007 for overall analysis and East Asian pulmonary tuberculosis group respectively. The cumulative Z-curve is represented by the solid blue line. The cumulative Z-curve crosses the trial sequential analysis monitoring boundary before reaching the required information size indicating sufficient cumulative evidences

Figure 6: (a) Trial sequential analysis of interferon-gamma +874T/A gene polymorphism in all the included studies. (b) trial sequential analysis of pulmonary tuberculosis cases in East Asian population. The required information size was calculated using two-sided α =0.05, β =0.20, relative risk reduction = 15% using the data of dominant model which was found to be 117,98 and 3007 for overall analysis and East Asian pulmonary tuberculosis group respectively. The cumulative Z-curve is represented by the solid blue line. The cumulative Z-curve crosses the trial sequential analysis monitoring boundary before reaching the required information size indicating sufficient cumulative evidences