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  Indian J Med Microbiol
 

Figure 5: The model depicting the cellular events involved in the emergence of rifampicin resisters from the antibiotic surviving phase cells formed upon exposure of the NCF and SCF cells to ×10 MBC rifampicin for prolonged duration. The NCF cells began elongation, multi-nucleation and multi-septation at 70 h, while the SCF cells began the same at 90 h. The images are not drawn to scale. NCF: Normal-sized cell-enriched fraction, SCF: Short-sized cell-enriched fraction, MBC: Minimum bactericidal concentration. The long red coloured cells are elongated multi-nucleated cells prior to multiple divisions at the multiple septae

Figure 5: The model depicting the cellular events involved in the emergence of rifampicin resisters from the antibiotic surviving phase cells formed upon exposure of the NCF and SCF cells to ×10 MBC rifampicin for prolonged duration. The NCF cells began elongation, multi-nucleation and multi-septation at 70 h, while the SCF cells began the same at 90 h. The images are not drawn to scale. NCF: Normal-sized cell-enriched fraction, SCF: Short-sized cell-enriched fraction, MBC: Minimum bactericidal concentration. The long red coloured cells are elongated multi-nucleated cells prior to multiple divisions at the multiple septae